For inkjet cartridges: Print heads may become clogged if the cartridge is left empty for an excessive period of time. It is always best to refill before the cartridge empties or soon after it empties. Clogged print heads can be unlcogged most of the time by soaking the cartridge print heads in our "cartridge and print head cleaner" solution for a few hours. As long as you refill your cartridge soon after it empties (preferably even before it is completely empty), you will minimize the risk of clogged print heads almost to 0%.
For toner cartridges: There are no print heads like the inkjets so this is not a concern.