The Uni-Kit refill kits are not messy if used carefully. The inkjet kit uses an injector system that allows you to accurately control the filling. The toner kit is as simple as 1-2-3 for most models (make a hole, fill with toner, close the hole). Generally, refilling an inkjet or a toner cartridge with the Uni-Kit systems should only take about 5 - 10 minutes.
For inks: The ink is not harmful unless ingested, so keep it out of reach of younger children and avoid contact with eyes. Wash affected areas with water, and if ingested or ill effects develop, call medical aid.
For toners: Much like the fumes released from gasoline in cars or from active or passive smoking or even from inert dust and chemicals in the environment, the exposure to fumes from toner or from burning a hole in the cartridge (when necessary) could of course be hazardous. To our knowledge, the average DIY refiller's exposure to fumes presents no significant health hazard in normal use. We recommend refilling in a well ventilated room or outside to minimize the exposure to fumes. For extra protection, wear a dust mask.